Fas-associated death domain protein (FADD) functions as an apoptotic adapter in mammals, recruiting caspases for death-inducing signaling complexes, while in lower animals, it interacts with IMD and DREDD to initiate antimicrobial responses. In this study, we examined the T. molitor FADD sequence (TmFADD) using molecular informatics methods to understand its involvement in the host's immune response against microorganisms. Knocking down TmFADD transcripts resulted in increased susceptibility of T. molitor larvae to E. coli, underscoring the significance of FADD in insect defense mechanisms and providing valuable insights into insect immunity.
Tenebrio molitor(T. molitor) is gaining attention as a sustainable food source with high nutrient content. Understanding their immune system, paricularly the role of Tak1 in the Imd pathway, is essential for mass breeding. This study investigates TmTak1 function in T. molitor. we investigated the immune function of TmTak1, followed by systemic infection using E. coli, S. aureus, and C. albicans. As a result, Silencing TmTak1 significantly affects expression levels of AMPs in the whole body, Fat bodies, and Integuments. These results showed lower expression levels of AMP compared to the control group during E.coli injection.
This study conducted a survey and evaluation on ‘The 2021 Jeju World Natural Heritage Festival’ with a framework of various stakeholders related to festivals. While aiming for the essential context of the celebration, we tried to find suggestions to ensure the continuity of the celebration and the designation of the World Natural Heritage. As a methodology, surveys and interview surveys were conducted in parallel with the framework of multifaceted evaluation. To summarize the important contents presented as policy suggestions, first, it is necessary to expand the concept of ' encounter with hidden nature' from the positivity of the concept of 'encounter with hidden nature' to have fellowship with mankind about natural heritage. For reference to this, efforts should be made to secure the continuity of the designation of World Natural Heritage through a contextual approach using the frame of 'encounter'. Second, since the participation of experts can help in many ways, it is necessary to encourage many experts to participate as a staff or activist. Third, it is necessary to sublimate Jeju's natural heritage into a public celebration without damaging it. Finally, it should be a festival centered on local communities and local residents. It is necessary to actively seek a system in which the World Natural Heritage Village Preservation Association, which will be created (tentative name), will be centered and promoted by the villagers.