Osteoarthritis is a degenerative change in the joint that causes damage to the articular cartilage, resulting in overexpression of inflammatory cytokine in the damaged chondrocytes, which leads to damage to the articular cartilage and is completely treated with antibiotics. We recovered the damage to the articular cartilage caused by osteoarthritis and investigated the effect of a low-molecular-weight collagen-based functional material without side effects. In this study, we investigated the ameliorative effects of YB in a monosodium idoacetate(MIA)-induced osteoarthritis rats. The experimental groups were divided with 5groups (n = 12) of SD rat: normal control(NC), MIA, MIA+L. plantarum (3×1011 CFU/ml), MIA+collagen and MIA+YB-21. Histological examinations indicated that YB-21 cartilage structure change, cartilage cell damage, and the loss of proteoglycan induced by MIA. Moreover, YB-21 reduced serum level expressions of, tumor necrosis factor-α(TNF-α), Interleukin6(IL-6), Interleukin1β(IL-1 β), Matrix metalloproteinase-9(MMP-9), Tissue inhibitor of metalloproteinases-1(TIMP-1). These results suggest that YB has a positive effect on osteoarthritis by restoring joint cartilage and anti-inflammatory effects due to the reaction of osteoarthritis in the MIA-induced rat.

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the colon and rectum with intervals of acute exacerbation. Its etiology remains unknown, although recent studies suggest that pro-inflammatory cytokines initiate the inflammatory responses. In this study, we investigated the ameliorative effects of YB-21 (new product containining Lactobacillus plantarum, Barley Bran and Nymphaeaceae) in a dextran sulfate sodium (DSS)-induced colitis in mice. The experimental groups were divided into 6 groups (n = 10) of ICR mice: normal control(NC), DSS-treated(PC, positive control), DSS+latic-L-treated (3×107CFU/ml), DSS+latic-M-treated (3×109CFU/ml), DSS+latic-H-treated (3×1011CFU/ml), and DSS+YB-21-treated. Histological examinations indicated that YB-21 suppressed edema, mucosal damage, and the loss of crypts induced by DSS. Moreover, YB-21 reduced serum level expressions of, tumor necrosis factor-α (TNF-α). These results suggest that YB-21 has an anti-colitic effect by the suppression of intestinal inflammatory responses in DSS-induced colitis in mice.