The Antarctic high plateau offers exceptional conditions for infrared and terahertz astronomy, as well as for programs requiring long, uninterrupted periods for measurements made with high cadence and photometric precision (i.e. time domain astronomy). In this review we summarise the special conditions of the Antarctic plateau which facilitate these observing regimes. We also outline some high profile science programs in each that could be conducted most effectively from the Antarctic high plateau, involving the first light in the Universe, the life cycle of our Galaxy, and the equation of state for the Universe. Three high plateau sites are under particular consideration for furthering such scientific programs-Dome A, Dome F and Ridge A. We summarise the activity underway at each site, which includes the building of new stations and the construction of facilities for optical, infrared and terahertz astronomy, as well as the plans for their future development.