Under the "Belt and Road" initiative, China's bilateral trade with countries participating in the "Belt and Road" ("B&R") initiative is constant and growing. The implementation of the "B&R" has made the development prospect of cross-border e-commerce very broad. In order to realize the rapid development of cross-border e-commerce, the cross-border e-commerce logistics that accompanies it plays a fundamental and supporting role. To make the cross-border e-commerce logistics smooth and efficient, it is inseparable from the coordinated development with other countries participating in the "B&R" initiative. At present, there are still many problems in cross-border e-commerce logistics cooperation between China and the countries participating in the "B&R" initiative, such as high logistics costs, long transportation time, low customs clearance efficiency, lagging logistics channel infrastructure construction and so on. Therefore, we should improve the mode of international transportation and accelerate the construction of cross-border e-commerce logistics overseas warehouses or border warehouses. Establish and develop a world electronic trade platform in countries participating in the "B&R" initiative to break the restrictions on China's participation in international trade such as the TPP. Explore the establishment of cross-border e-commerce intelligent logistics system, and gradually improve the level of logistics information and specialization, and establish the information sharing system. Focus on building the cross-border e-commerce comprehensive pilot area "big data center". Thus accelerating the development of cross-border trade with countries participating in the "B&R"initiative.