Since the beginning of 2020, Corona-19 has broke out and spread around the world. In order to control the epidemic, China has adopted a series of measures such as delaying the resumption of work and production of enterprises, compulsory closure of restaurant and entertainment business, which have effectively contained the spread of the epidemic to a large extent. However, a series of policies in response to the epidemic have also traumatized the economy. In particular, it has caused great difficulties to the operation of small and medium-sized enterprises. This article conducted a questionnaire survey on the status of SMEs (small and medium-sized enterprises) affected by the epidemic. The results of the survey show that 85% of SMEs have a cash balance that is able to support operation for less than 3 months, indicating that SMEs have a high risk of financial vulnerability, and most SMEs face the risk of capital disruption and crisis. The central and local governments have successively issued hundreds of policies to help small and medium-sized enterprises overcome the difficulties. In addition to the well utilization of supporting policies of the government, small and medium-sized enterprises should seek self-help and development based on their own particularly on the working capital management. In this process, small and medium-sized enterprises need to be more conservative, pay attention to reducing expenditure, try to save cash by negotiation and signing agreements etc. and set scientifically credit conditions, use the Internet to strengthen cooperation, expand sales channels and smoothly survive this difficult epidemic period.