In this paper, the vibration control effect of the isotropic damping devices (so-called Kagome dampers) was investigated by applying the Kagome dampers to a 20-story frame structure apartment. A new Kagome Damper System (KGDS) composed of the dampers and supporting column was proposed and numerical analyses were performed to investigate the effects of stiffness ratio between controlled structure and supporting column, the damper size and the number of the dampers. The numerical analysis results of a structure with KGDS up to the third story showed that the stiffness ratio should be higher than 6.4 and the damper size be at least 700×700mm to effectively reduce the base shear and the maximum drift of the uppermost story. When the KGDS was installed up to the fifth story, the stiffness ratio should be higher than 7.0 and damper size needs to be at least 500×500mm for obtaining the target performance