Among the costs composing the life-cycle cost of nuclear containment, the expected loss due to leakage of radioactive material is usually exorbitant, and it takes large amount in the evaluation of life-cycle cost. This study presents a process to determine optimal target reliability for nuclear containments, mainly focuses on its expected loss. It is estimated considering the surrounding environment of nuclear containment. Target reliability of containments having different lifespan can be determined by revising the expected loss estimated from the 20, 40 and 60 years of operation.