The major goal of this article is to find missiological implications of the fruit of the Spirit(love, joy, peace, patience, kindness, goodness, faithfulness, gentleness, and self control) in Galatians 5:22 by investigating John Wesley’s and others’ writings. Because the author believes that attitude is strongly contagious in mission fields, he especially aims to suggest that the fruit of the Spirit would supply some valuable hints for proper missionary attitude.The first half of this article deals with John Wesley(1703-1791) and the fruit of the Spirit. Unlike some theologians who divide the fruit of the Spirit into three or four portions, Wesley regards the fruit of the Spirit as an indivisible whole. Wesley does draw a distinction between extraordinary gifts of the Spirit and ordinary gifts of the Spirit. However, to Wesley, the fruit of the Spirit is more than merely the gifts of the Spirit. It is synonymous with Christian perfection. Wesley’s view of the fruit of the Spirit is congruent with the verse “Your attitude should be the same as that of Christ Jesus”(Phil. 2:5).The second half of this article handles missiological implications of the fruit of the Spirit. In order to do so the author applies insights from Thomas Keating, Elisa Morgan, Evelyn Underhill, Philip D. Kenneson, James Merritt, Viv Grigg, and the Bible. Among these, the subtitles of Merritt’s nine chapters are worth mentioning: If you’re not loving, you’re not living; Joy to the world; How to keep your head while others are losing theirs; Winners never quit and quitters never win; Try a little kindness; How to live the good life; The world’s greatest ability; The lower you get, the higher you go; Never let them see you sweat.The author concludes this article by emphasizing that intercultural missionaries should be deeply purged good soil and stay close (not to the sender or to the host people but) to Jesus in order to be fruitful. The perfecting or maturing of the Christian character is what the fruit of the Spirit is all about.