The vast writings on the Reformation and the Modern science have produced in terms of either-or. In other words, the relations between the Reformation and the Modern science have interpreted either in negative way or in positive way. The negative interpretations hold that the Reformation would have had little effect on modern scientific revolution. On the other hand, the positive interpretations argue that specific doctrines or attitudes affirmed by the Reformers and their followers contributed directly or indirectly to the growth of modern science. After brief discussion of each of these interpretations, this paper will claim that the correlationship of the Reformation and the Modern science would be explained more clearly when interpretations of their relation are explored in terms of Calvin’s principle of accommodation. For Calvin, accommodation is related to his understanding of God. According to Calvin, God reduces or adjusts to human capacities in order to reveal the infinite mysteries of his being. Because his mysteries are beyond the powers of human being to grasp. The paper will try to reveal the importance of Calvin’s accommodation theory through his understanding of nature. For Calvin, the world of nature represents traces of God’s handiwork. The world is a “mirror”, in which God may be viewed. Therefore, Calvin was intensely interested in exploring of nature. The attitude of Calvin toward nature enabled science to able to penetrate more deeply into the secrets of divine wisdom. Consequently, the paper shows that complexities of relation between the Reformation and the rise of modern science appears to be many-sided. In addition, this paper demonstrates that it is noteworthy to note the relations of religion and science in the Reformation era as an important instance historically.