This article aims to offer the changing and missional response to the Middle East from social, cultural, and religious perspectives. The paper explains causes of Jasmine Revolution; such as lack needs of human being, reject about absolute power, and social network. Consequently, Jasmine Revolution came out democracy in the Middle East countries, and social participation and change of women. In this countries, the role of women in the great upheaval in the Middle East has been woefully under-analysed. Women in Egypt did not just join the protests – they were a leading force behind the cultural evolution that made the protests inevitable. And what is true for Egypt is true, to a greater and lesser extent, throughout the Arab world. When women change, everything changes, and women in the Muslim world are changing radically. I think that Christians mission forms in the Middle East, As an indigenous community their displacement would cause a fundamental change to the identity of the region and its future development. Their contribution to the civilization society, trust and position of Islam women is immense changing. Thus, the Christian mission should be introduce being of Jesus Christ and the spirit of God. I now have a clearer contemporary perspective on Christianity mission in the Middle East. While many Christian mission can do appreciate the consideration of the Middle East, in the place where Christianity originated, it is tried to Muslim people.