This study deals with optimized structural analysis of stainless rectangular water reservoirs with 5,000ton capacity for various combined load cases. The objective of this study is to propose most efficient structural models through the comparison of various model cases. In order to perform an optimized analysis, three dimensional finite element analyses are carried out for large sized models. The numerical results obtained provides the detailed size and thickness for optimal design of water reservoir. In particular, results reported in this paper show the influence of various types of loading and dimensions of the wall and stiffened column on the structural behavior of the large sized water tanks.