The objective of this study is to analysis the seismic response of 200m spanned honeycomb lattice domes under horizontal and up-down ground motion of El Centro earthquake. For the analysis of seismic response of the honeycomb lattice domes by rise/span ratio, the time history analysis is used for the estimation of the dynamic response. The low rise lattice dome is less deformed and less stressed than the high rise lattice dome for the earthquake ground motion. The 3-dimensional earthquake response is not significantly different the dynamic response of one directional ground motion. The earthquake response of domes with LRB isolation system is significantly reduced for the asymmetric vertical deformation and the horizontal and vertical accelerations.