The objective of this study was to compare the differences between males and females in the mediating effects of academic failure tolerance on the impact of self-efficacy on game addiction among adolescents. The results are summarized as follows. First, in both men and women, self-regulation, one of sub-variables of self-efficacy, had negative effects on game addiction. Second, in men, both emotion and behavior had negative effects on game addiction, while, in women, only behaviour did so. Third, among sub-variables of self-efficacy, in males, self-regulation and task difficulty had positive effects on academic failure tolerance, while, in women, self-regulation, confidence, and task difficulty did so. Fourth, testing the mediating role of academic failure tolerance in the effect of self-efficacy on game addiction showed that there was a partial mediating effect among males, while there was a perfect mediating effect among females. All this implies that there is a need to develop programs that help students maintain positive emotions and behaviors even after they have experienced academic failure, considering the importance of academic failure tolerance for students.