Pollutants removal and disinfection effect of secondary effluent from final settling tank of sewage treatment plant of W city were investigated in Loop Reactor using ordinary granular activated carbon(GAC) and GAC coated with silver nanoparticles. The results showed that the removal efficiency of CODMn, T-N and T-P using GAC with silver nanoparticles were higher than using the ordinary GAC. The removal efficiency of T-P using GAC with silver nanoparticles is 45.4% and that of T-P using ordinary GAC is 30.9% in the same case of the input amount of 20 g/L of GAC. The total califorms is reduced according to increasing input amount of GAC with silver nanoparticles and ordinary GAC. The disinfection efficiency of total coliforms in case of GAC with silver nanoparticles is much higher than that in case of ordinary GAC. For all experiments using the silver nanoparticles, the total coliforms is under 26 cfu/mL and this shows very excellent disinfection effect.