In an automated industry PLC plays a central role to control the manufacturing system. Therefore, fault free operation of PLC controlled manufacturing system is essential in order to maximize a firm's productivity. On the contrary, distributed nature of manufacturing system and growing complexity of the PLC programs presented a challenging task of designing a rapid fault finding system for an uninterrupted process operation. Hence, designing an intelligent monitoring, and diagnosis system is needed for smooth functioning of the operation process. In this paper, we propose a method to continuously acquire a stream of PLC signal data from the normal operational PLC-based manufacturing system and to generate diagnosis model from the observed PLC signal data. Consequently, the generated diagnosis model is used for distinguish the possible abnormalities of manufacturing system. To verify the proposed method, we provided a suitable case study of an assembly line.