This study was performed to establish the control strategies effectively using Eco-friendly agricultural materials (EFAM) and natural enemy when cultivating autumn-type leaf perilla and to investigate the population densities of seasonal major pests such as Tetranychus urticae (two-spotted spider mite, TSSM), Broad mite (Polyphagotarsonemus latus), Aphis egomae, and Pyrausta panopealis. TSSM showed the occurrence in the seedling stage from August to the end of September and controlled using EFAM in the nursery. Broad mites had a low occurrence in October, December, and the following year showed the density of two or more leaves per leaf from February. Aphis egomae was locally prevented around the area of occurrence, and it showed more than five per leaf in October. Pyrausta panopealis seemed to occur from August to September. Aphis egomae is control using high-toxic EFAM before the overwintering and prevents it from using banker plants planted barley in the winter. Pyrausta panopealis is protected by biological pesticides in August registered in the leaf perilla.