This study focused on developing a comprehensive strategy for effective missions in North Korea in light of holistic mission. North Korea is a closed nation which calls for some practical mission strategies to be evangelized according to divine providence. Both the work of Holy Spirit and the work of the missionaries are essential to extend the kingdom of God in North Korea. First of all, this study pointed out the importance of developing a comprehensive mission strategy. The mission strategy is based on the concept of Missio Dei (God’s Mission) and the perspective of God‘s kingdom. In other words, both ecumenical and evangelical approaches are needed for a holistic mission in North Korea. This study found out six mission strategies as follows: First, rebuild churches in North Korea through the existing house churches. Second, focus on the people who have escaped from North Korea for freedom. Third, encourage NGO (Nongovernmental Organizations) missions. Fourth, carry out missions in cooperation with the North Korea Christian Federation. Fifth, pursue peaceful unification between North and South Korea. Sixth, carry out missions through Koreans who are living in China. Extending God’s kingdom in North Korea can be possible when some practical mission strategies are well developed and effectively applied. The mission strategies as well as the church’s ministries need to be contextualized so that the Gospel message can be meaningfully communicated to the people. As a result, a lot of true disciples of Jesus Christ can be produced. God will be glorified when many people in North Korea experience becoming a Christian. All Christians in North and South Korea need to arise and shine God‘s light to the world. “Arise, Shine, for your light has come, and the glory of the Lord rises upon you.” (Is. 60:1).