Purpose: This study aimed to explore the psychoemotional changes experienced by mothers of children diagnosed prenatally with congenital heart disease. Methods: Data were collected from March 1 to November 3, 2022, through in-depth interviews with 10 mothers of babies diagnosed prenatally with congenital heart disease in a tertiary hospital. Data were analyzed using Braun and Clarke’s thematic analysis method. Results: The following four themes, with 16 subthemes, were identified: 1) Contemplating maintaining the pregnancy amidst grief and denial, 2) Actively protecting the baby, 3) Recognizing the reality of the disease progression while facing the baby, and 4) Finally becoming a mother. Conclusion: The findings suggest that medical staff should provide accurate information about any disease a baby is diagnosed with before childbirth, understand mothers’ psychoemotional changes, and effectively utilize prenatal counseling. This can be achieved by further expanding the existing patient- and family-centered nursing intervention program implemented by the hospital.