Constitutive modeling of constituent materials is very important for reinforced concrete (RC) frames. Cyclic constitutive behavior of unconfined concrete, confined concrete and reinforcing steel should be well defined in fiber-based discretization of RC sections. This study performs nonlinear dynamic analyses of RC frame structures to investigate the sensitivity of seismic behavior of such frames to different constitutive models of constituent materials. The study specifically attempts to examine confinement effects in concrete modeling and degrading effects in steel modeling, which substantially affects the monotonic, cyclic and seismic responses of RC members and frames. Based on the system level analysis, it is shown that the response of non-ductile frames is less sensitive to confined concrete models while the modeling of reinforcing steel is quite influential to the inelastic response of both non-ductile and ductile frames.