In treatment of right ventricular failure with pulmonary hypertension, milrinone has not only an inotropic effect but also a vasodilating effect, thus, recently, it has been widely used. Recent studies have reported on the direct stimulation effects of doxapram on the central nervous system. A 91-year-old female underwent hemiarthroplasty under spinal anesthesia. When transported to the recovery room, right ventricular failure, cardiogenic shock, and mental deepening occurred. After stabiliz-ing vital signs, milrinone, doxapram was administered. We report on the effective use of milrinone for acute right ventricular failure and the active use of doxapram for reduced consciousness and hypoventilation.