A ten-year-old female Yorkshire terrier was presented to Veterinary Medical Center, Chungbuk National University with signs of anorexia and cough. Blood electrolytes, complete blood count (CBC), and hormone analysis revealed mild elevated lipase and bile acid, moderate hypercholesterolemia and severe elevated alanine transaminase (ALT), alkaline phosphate (ALP), and gamma-glutamyl transferase (GGT). Survey radiographs revealed the potbelly-shaped abdomen, generalized hepatomegaly, and round and smooth marginated mass in right upper abdomen. On ultrasonography, enlarged gallbladder with combination of kiwifruit-like and stellate pattern consistent with gallbladder mucocele was revealed. On day 113 after diagnosis of gallbladder mucocele, free fluid and the hyperechoic structure mainly in the dorsolateral region of the gallbladder was found, which was consistent with gallbladder rupture. Cholecystectomy was performed after gallbladder rupture.