Purpose: The purpose of this study was to provide basic data to interview programs for assisting male college students adjust to clinical practice by understanding the meaning of stress in such a practice. Method: Individual in-depth interviews using open-ended questions were conducted with students. Data were collected in August 2018, and analyzed using Colaizzi’s phenomenological method. Results: The categories of practical experiences in the interview programs for mediating gender conflicts in male nursing students were clearly recognized as, “experiencing limits of practice on female patients,” “a sense of burden representing practical students,” and “forcing of manhood.” The essential themes of participants' experiences in simulation programs included: “Prejudice and unfairness in having a female-related job,” “Women’s hospital practice is limited,”-“Attention is focused on themsince they are ‘minorities’,” “Uncomfortable interpersonal relations in clinical practice,” “The patience of a discriminative perception that physical labor should be mobilized, requiring forceful leadership,” “Live in a way that society prefers.” Conclusion: This study attempted to understand the meaning and nature of experiencing stress among male college students in clinical practice by applying Colaizzi’s method of analysis in phenomenology nursing research. In order to assist participants understand women's mainstream clinical practice, preparing separate programs is important.