To investigate the reason for the spatial difference in PM2.5 (Particulate Matter, < 2.5 ㎛) concentration despite a similar synoptic pattern, a synoptic analysis was performed. The data used for this study were the daily average PM2.5 concentration and meteorological data observed from 2016 to 2020 in Busan and Seoul metropolitan areas. Synoptic pressure patterns associated with high PM2.5 concentration episodes (greater than 35 ㎍/㎥) were analyzed using K-means cluster analysis, based on the 900 hPa geopotential height of NCEP (National Centers for Environmental Prediction) FNL (Final analysis) data. The analysis identified three sub-groups related to high concentrations occurring only in Busan and Seoul metropolitan areas. Although the synoptic patterns of high PM2.5 concentration episodes that occur independently in Busan and Seoul metropolitan areas were similar, there was a difference in the intensity of pressure gradient and its direction, which tends to be an important factor determining the movement time of pollutants. The spatial difference in PM2.5 concentration in the Korean Peninsula is due to the difference and direction of the atmospheric pressure gradient that develops from southwest to northeast direction.