In order to increase the usability of PLA in tissue engineering, we tried to improve the hydrophobicity and low mechanical properties of PLA. The basic solutions were prepared by mixing 3, 5, and 7wt.% of PLA in a solution of chloroform and acetone in a volume ratio of 3:1. Several types of nanofiber mats were fabricated using a mixed solution in which 0.5, 1, and 3wt.% of PEO and PVAc, which are biodegradable polymers, were added to these solutions, respectively, through the SBS method. As a result, it was found that when the content of PEO increased, the diameter and surface state of nano fibers became uniform and the water contact angle significantly decreased, but it did not affect the tensile strength. In addition, the hydrophobicity of PLA was improved to hydrophilicity by mixing with PVAc, but the strain was greatly reduced.