With increasing demands of transportation services for disabled or aged people, who need wheelchairs, it is recommended to install wheelchairs inside automotive vehicles. However, wheelchairs are not effectively safe devices during car crash unless they are properly fixed. So far, few data have been found related to wheelchair safety or characteristics during car crash, therefore, frontal crash simulations have been carried out based on the FE models of a dummy and a conventional wheelchair including the wheelchair fixing belts and the install plate in the present study. Head injury criteria (HIC) and motion criteria (MC) are investigated and the optimum value of the design variable was found by the Robust design.