Inline mixer, mixing device combined mechanical and hydraulic mixing, has been demonstrated many times to be effective in mixing process for coagulation. But most of inline mixer are difficult to utilize in relevant domestic industry since it is a foreign technology. So the development of domestic inline mixer is strongly needed. In this study, we compared mixing characteristics through computational fluid dynamics(CFD) analysis with different shape of impeller for the development of domestic inline mixer. The shape of the flow field by velocity vectors and the concentration distribution of injected coagulant were analyzed for comparison of the results. We chose two shapes of impeller(plate and screw), the CFD analysis for them was conducted to simulate actual field conditions. The screw-shaped impeller showed more well-mixing characteristics than the plate-shaped impeller from the results. On the other hand, short-circuiting flow could occur when the shape of impeller was plate.