Purpose: This study was conducted to assess the post-discharge experiences of caregiving mothers of pediatric patients with intestinal failure who were receiving home TPN treatment. Methods: This was a qualitative study utilizing Colaizzi’s phenomenological research method. The eight participants were mothers of pediatric outpatients from the short-gut syndrome clinic at a tertiary hospital in Seoul who were continuing home TPN treatment through a CVC. Data were collected from January to May 2022 through individual in-depth interviews, and analyzed. Results: Analysis of 127 meaningful statements from the mothers identified 12 themes and 36 sub-themes, organized into five categories: “Mixed emotions regarding hospital discharge”, “Problems after discharge”, “Stress in everyday life”, “Support from nurses and family members”, and “Looking to the future”. Conclusion: The study results provided insights into the meaning and value of the post-discharge experiences of mothers of pediatric patients with intestinal failure. These findings will be valuable in the development of interventions to provide education and other support measures for primary caregivers of children with intestinal failure.