The purpose of the present study was to investigate the effects of familiar exercise and novel exercise on motor function after intracerebral hemorrhage (ICH) in rats. The rats were subjected to a unilateral striatal ICH via collagenase infusion. The rats were randomly divided into the following three groups: the CON (control group; rested one week post-ICH), the FE (familiar exercise group; familiar exercise was performed two weeks after one-week post-ICH period), and NE (novel exercise group; novel exercise was performed two weeks after one-week post-ICH period). We measured neurological behavior using a ladder rung walking test and a beam walking test; we measured the level of nerve growth factor (NGF) using immunohistochemistry and western blot analysis. We performed a one-way ANOVA test to analyze the scores obtained from the neurological behavior tests and the differences of NGF protein levels among the three groups. In the present study, the FE group and the NE group showed significant improvement during the neurological behavior tests and in their expression of NGF protein level, as compared to the CON group. Especially, NE group more increase than FE group in neurological behavior tests, the expression of NGF on motor cortex. In conclusion, these results suggest that, after ICH, familiar exercise and novel exercise enhance motor function and, novel exercise is more effective than familiar exercise.

The purpose of this study is to examine the effect of transfer of training approach on cognitive function and functional recovery and the difference in the stroke patterns of adult stroke patients with affected cognitive function. Twenty stroke patients were participated ; 8 males and 12 females, the age ranged from 34 to 73. By the classification of diagnosis, 10 subjects were cerebral infarction and 10 subjects were cerebral hemorrhage, by the classification of affected side, 11 Rt hemiplegic patients, 9 Lt hemiplegic patients who were above at least post onset 2 month to a year. It was evaluated and analyzed pre and post treatment with MMSE and FIM, and the method of transfer of training approach was practiced every 30 min a day for a month. The data were analyzed by t-test and one way ANOVA. The results of this study were as follows: 1. There was significant in the effect of transfer of training approach on cognitive function of stroke patinets. 2. There was significant in the effect of transfer of training approach on functional recovery of stroke patients. 3. There was a significant difference in the effect of treatment in the group of cerebral infarction.