Notwithstanding the existence of The Act on the Establishment of Safe Laboratory Environment to prevent accidents in laboratory, it has not been secured substantive level of safety. Moreover, it is hard to apply to the scope of responsibility when the accident occurs in laboratory with The Occupational Safety and Health(OSH) Act. Thus, it is necessary to review and compare the OSH Act and The Act on the Establishment of Safe Laboratory Environment to reinforce the safety in laboratory.