In this study, a hybrid cooling system combining thermoelectric modules and a vapor compression cycle was applied to a cold storage unit, and the effect of enhancing energy efficiency through the application of mist spraying technology to the heat exchanger coils was analyzed. The hybrid cooling system was designed to operate the vapor compression cycle during the initial temperature reduction phase (from ambient to 5°C), and to maintain the set temperature using thermoelectric modules thereafter. Separate heat exchangers were installed for the thermoelectric and vapor compression components, and mist spraying was applied individually to each heat exchanger coil. Experimental results showed that mist spraying reduced power consumption by approximately 20% during vapor compression operation, and by about 1~2% during thermoelectric operation. This study empirically demonstrates the potential of mist spraying technology as an energy-saving enhancement for hybrid cooling systems, and the findings can serve as a foundation for the development and commercialization of integrated heat exchangers in the future.