In the region of the open cluster M48 (NGC 2548), time-series BV CCD images were taken for 22 nights from February 28 in 2008 to March 17 in 2011. From this observation, we found 10 new variable stars. They include five eclipsing binaries, an RR Lyrae, two δ Scuti, and two semi-periodic and/or slow irregular type variable stars. We fail to find the member stars of the open cluster among the 10 variable stars.