PURPOSES : This study evaluates the effectiveness of traffic flow optimization when giving safety strategy guidance to a connected autonomous vehicle (CAV) based on information received through infrastructure cooperation in a V2X environment for non-signal intersection. METHODS : To evaluate the effectiveness of safety strategy guidance based on developed traffic flow control algorithm at a non-signalized intersection, it was implemented on simulation. A scenario based on the Level of Service (LOS) and the market penetration rate(MPR) of autonomous vehicles was established. The simulation results were divided into safety, operation, and environment to evaluate the effect, and the effect of optimizing traffic flow was finally derived through the integrated evaluation score. RESULTS : As a result, when safety strategy guidance was provided, the number of conflicts and CO emissions decreased by about 29% and about 15%, improving safety and environmental performance. In the case of operation, the mean of delay time was increased overall by 1%, but in the case of MPR 50 and above, the delay time was reduced by about 38%, thereby increasing operation. Finally, the aspect of traffic flow optimization, effectiveness of safety strategy guidance was derived through the integrated evaluation score, and the average integrated evaluation score improved from MPR 20 or higher. CONCLUSIONS : Providing guidance had the effect of optimizing traffic flow at a non-signal intersection. In the future, V2X communications will provide CAV with algorithm-based guidance developed in this study to control driving behavior. it will support safe and efficient driving at non-signal intersections.