This study intended to analyze an influence of the structure elements on the optimal location for one-outrigger system in tall building by using MIDAS-Gen. In this investigation, the analysis parameters were the outrigger position and the stiffness of main structure elements such as shear walls, outrigger systems, exterior columns connected in outrigger system and frames not to be connected in outrigger system. For the objective of finding out the optimal location for one-outrigger system in high-rise building, we studied the lateral displacement in top level of 80 stories building. The results of this study indicated that the outrigger location and the stiffness of main structure elements such as shear walls, outrigger systems, exterior columns connected in outrigger system and frames not to be connected in outrigger system had an influence on the optimal location of one-outrigger system. In addition, it is showed that the research results can be very useful in obtaining the structure design data for looking for the optimal location of one-outrigger system in high-rise building.