Sabotage on nuclear power plants are of great national and social significance and long-term damage, the IAEA’s “Nuclear Security Recommendations on Physical Protection of Nuclear Material and Nuclear Facilities (INFCIRC/225/Rev.5) provides a standard direction for physical protection of their nuclear facilities in almost all member countries, including Korea and the United States. In the United States, Federal Law 10 CFR Part 73, Sections 73.40 to 73.57 specify requirements for physical protection of nuclear power plants, performance criteria, physical protection systems and components thereof, core information, and physical protection for key activities related to nuclear power plant operations. Accordingly, the USNRC carefully examines whether the plant meets the physical protection objectives and criteria set out in SRP 13.6.2, whether the core area/protection area is properly set up to protect against internal and external physical attacks, sabotage threats, and what design measures and facilities are being set up for these areas. The Department of Homeland Security (DHS), established in 2002 following the 2001 World Trade Center attacks, authorized federal, local governments, and authorities National Infrastructure Protection Plan (NIPP) to protect facilities from terrorist attacks and man-made physical attacks in 2007. NIPP clarifies the great principles and governance of the physical protection of national infrastructure in the United States presented by DHS. There are many physical protection design guidelines and technical standards for preventing attacks from terrorists or internal and external sabotage attackers, improving the viability of mitigating the damage in case of emergency, and achieving efficient recovery from such damage. Particularly important, small-scale damage/damage at a particular location of a major facility is extended to the entire facility, resulting in asymmetrical large-scale damage, so-called “Progressive Collapse” under initial attack loads, minimizing local damage, and protecting the building’s integrity through isolation from other structural components. Consequently, this paper deal with physical protection system design on Unite states standards and practices for applying to physical protection system design in Republic of Korea.