The growing logistics strategy of a company is to optimize their vehicle route scheduling in their supply chain system. It is very important to analyze for continuous pickups and delivery vehicle scheduling. This paper is a computational study to investigate the effectiveness of continuous pickups and delivery vehicle routing problems. These scheduling problems have 3 subproblems; Inbound Vehicle Routing Problem with Makespan and Pickup, Line-haul Network Problem, and Outbound Vehicle Routing Problem with Delivery. In this paper, we propose 5 heuristic Algorithms; Selecting Routing Node, Routing Scheduling, Determining Vehicle Type with Number and Quantity, and Modification Selecting Routing Node. We apply these Algorithms to S vehicle company. The results of computational experiments demonstrate that proposed methods perform well and have better solutions than other methods considering the basic time and due-date.