본 논문에서는 모듈화(Module)된 부품을 활용한 탄성받침 성능개선기법에 대하여 소개하였다. 각각의 모듈화된 장치들이 지진 강도 및 이동 변위에 따른 단계별 거동을 함으로써 받침의 성능을 개선하게 된다. 모듈화된 장치들은 초기전단저항 블럭, 완충장치, 변위수용가이드, 낙교방지블럭이 있으며, 탄성받침에 추가적으로 적용되었다. 이 장치는 지진의 규모에 따라 4단계로 거동하며, 1차로 설계변위를 수용하고, 2차, 3차에서는 대규모 지진을 수용하며, 4차로는 대규모의 지진에 대해서 낙교방지가 가능하도록 설계되어 탄 성받침의 용량 제한을 증가시킨다. 본 논문에서는, 개발기술인 PRB 지진격리장치를 유한요소해석을 통해 해석하여 격리장치의 이론적인 거동이 구현되는지와, 대규모 지진에 해당하는 하중을 견딜 수 있는지 확인하였다. 그리고 이를 바탕으로 실험을 통해 성능평가를 진행하여 두 결과의 비교 분석을 통해 PRB 지진격리장치가 탄성받침의 성능을 개선할 수 있는지 검증하였다.

The previous studies of p16^INK4a, pRb, p53, and Ki-67 expression suggested that these markers may be preferentially expressed in cervical neoplasms. The purpose of this study was to assess the expression and the clinical significance of p16^INK4a, pRb, p53, and Ki-67 proteins in cervical lesions. We obtained 106 cases with various categories of cervical squamous mucosa, including squamous cell carcinoma (n=35), cervical intraepithelial neoplasia (CIN) II/III (n=26), CIN I (n=10), squamous metaplasia (n=15), and normal squamous mucosa (n=20). Immunohistochemical staining was performed for p16INK4a, pRb, p53, and Ki-67 proteins in formalin-fixed and paraffin-embedded tissue sections of the uterine cervix. Evaluation of immunohistochemical staining was based on the frequencies of expression and the mean immunoreactivity scores (IS) in each diagnostic category. p16INK4a positive sotaining was observed in 26 of 35 cases (74.3%) of squamous cell carcinoma, in 16 of 26 cases (61.5%) of CIN II/III, in six of 10 cases (60%) of CIN I, in nine of 15 cases (60%) of squamous metaplasia, and negative in normal squamous mucosa. pRb expression was detected in all diagnostic categories; however, the proportion of pRb positive cells was relatively decreased in CIN II/III (38.5%) and squamous cell carcinomas (51.4%), compared to normal squamous epithelium (90%) and squamous metaplasia (73.3%). No significant differences in expression of p53 were observed in any diagnostic categories. Ki-67 expression was increased in squamous cell carcinoma (37.1%), CIN II/ III (42.3%), and CIN I (40%), but negative in squamous metaplasia and normal mucosa. In 35 cases of squamous cell carcinomas, multivariate analysis revealed no differences in p^INK4a, pRb, p53, and Ki-67 expression according to the age of the patient, lymph node metastasis and clinical stage. In conclusion, the combined use of p16^INK4a and Ki-67 immunoreactivity could improve the diagnostic specificity of squamous cell carcinoma of the uterine cervix.