A institute developed Quality Assurance(QA) program for nuclear R&D projects to meet the demands of its customers' requirements for recognized quality standards and nuclear industry accepted practices. It was implemented by project quality assurance plan as a new process. This paper is designed to introduce the process of establishment and execution of nuclear quality assurance programs for R&D as a case study. This QA program can be used as a reference to other organization on implementation of QA for R&D projects.