The purpose of the study was to find grey matter (GM) and white matter (WM) volume reduction in the brain reward system among patients with alcohol dependency. This study investigated regional GM and WM in chronic alcoholic patients, focusing primarily on the reward system, including principal components of the mesocorticolimbic reward circuit as well as cortical areas with modulating and oversight functions. Sixteen abstinent long-term chronic alcoholic men and demographically matched 16 healthy control men participated in the study. Morphometric analysis was performed on magnetic resonance brain scans using voxel-based morphometry (VBM)-diffeomorphic Anatomical Registration through Exponentiated Liealgebra (DARTEL). We derived GM and WM volumes from total brain and cortical and subcortical reward-related structures. Morphometric analyses that revealed the total volume of GM and WM was reduced and cerebrospinal fluid (CSF) was increased in the alcohol group compared to control group. The pronounced volume reduction in the reward system was observed in the GM and WM of the nucleus accumbens (NAc), GM of the amygdala, GM and WM of the hippocampus, WM of the thalamus, GM and WM of the insula, GM of the dorsolateral prefrontal cortex (DLPFC), GM of the orbitofrontal cortex (OFC), GM of the cingulate cortex (CC), GM and WM of the parahippocampal gyrus in the alcohol group. We identified volume reductions in WM as well as GM of reward system in the patients with alcohol dependency. These structural deficits in the reward system elucidate underlying impairment in the emotional and cognitive processing in alcoholism.

해수면 온도에 대한 구름복사 강제력의 지역 의존도가 조사되었다. 이 조사는 경년 변동과 계절 시간규모에 대해서 각각 조사되었다. 적도 동태평양에서 경년 변동의 경우 해수면 온도가 1˚C 증가할 때 순 구름복사 강제력은 약 3Wm-2가 증가하였으며, 계절변동이 포함된 경우 약 3.5Wm-2가 증가하는 것으로 나타났다. 반면 열대 해양전체에서 경년 변동의 경우 해수면 온도가 1˚C 증가할 때 순 구름복사 강제력은 1.5Wm-2 감소하였으나, 계절변동이 포함된 경우 약 2.9Wm-2로 증가하였다. 따라서 해수면 온도에 대한 구름복사 강제력의 의존도는 적도 동태평양에서 열대 해양으로 넓어질수록 경년 변동에 의해 영향에서 계절변동에 의한 영향이 더 지배적으로 작용한다. 계절 변동이 포함된 경우 해역에 관계없이 해수면온도가 1˚C 증가할 때, 순 구름복사 강제력은 약 2∼3Wm-2 증가하였다. 이러한 결과는 해수면 온도의 경년 변동이 뚜렷한 적도 동태평양에서는 경년 변동에 의한 구름복사 강제력이 대기를 가열하는 반면, 열대 해양 전체에서는 계절변동에 의한 구름복사 강제력이 대기를 가열한다는 것을 의미한다.

Development of transportation and communication technology has affected our daily life and has caused to separate residential places from working places. Particularly in rural areas, the life zones are incorporated into larger towns or urban areas due to their lack of cultural, social and economic infrastructures. Thus, the analysis of the depended region and the life zone is important for the planning of regional revitalization programs and related project. The purpose of this study is to propose a regional dependency model (RDM) using the origin-destination(O-D) matrix of commuters and compare it with the Nystuen & Dacey model for regional correlation. The regional characteristics are analysed and our RDM were tested using the commuting data on Seoul metropolitan area(Seoul, Gyeong-gi, Incheon) and Chungchung area. The regional correlation model can only explain the determination of regional interaction without considering the direction of regional correlation but our model can show the direction of regional dependencies.