Reversible cerebral vasoconstriction syndrome (RCVS) is a clinic-radiologic syndrome characterized by severe headache and reversible multifocal arterial constrictions that resolve within 3 months. RCVS can be either spontaneous or related to a trigger, such as vasoactive drugs. The authors present the case of a 53-year-old woman who presented with recurrent thunderclap headache. Initial computed tomography angiography demonstrated segmental vasoconstriction of bilateral anterior cerebral arteries. Fourteen days after, initial vasoconstriction was improved as determined by follow up CT angiography. Our patient had recurrent thunderclap headache for a considerable time (around 24 months). However, although she visited many hospitals, the headache was not controlled by any treatment. Fortunately, she did not have any neurological complication and her symptoms relieved after nimodipine treatment. Clinicians should be aware of possible RCVS when a patient has recurrent thunderclap headache for a protracted period.