In this study, the anti oxidative effects, inhibitory effects on elastase, and components of Securinega suffruticosa extracts were investigated. The free radical (1,1-diphenyl-2-picrylhydrazyl, DPPH) scavenging activities (FSC50) and reactive oxygen species ROS) scavenging activities (OSC50) of extract/fractions from Securinega suffruticosa were measured. The aglycone fraction (9.04 ± 0.51 μg/mL) and 50 % ethanol extract (1.05 ± 0.41 μg/mL) showed the most effective scavenging activities. The protective effects on the rose-bengal sensitized photohemolysis of human erythrocytes were investigated. The aglycone fraction exhibited the most prominent cellular protective effect (τ50, 102.77 ± 5.37 min at 10μg/mL). The inhibitory effect of ethyl acetate fraction on tyrosinase were of examined (210.0 ± 1.02 μg/mL). The inhibitory effect of aglycone fraction on elastase were also investigated (17.6 ± 1.26 μg/mL). These results indicate that extract/fractions of Securinega suffruticosa can function as antioxidants in biological systems, particularly skin exposed to UV radiation by scavenging 1O2 and other ROS, and protect cellular membranes against ROS. Securinega suffruticosa extract could be used as a new cosmeceutical ingredient for whitening and anti-wrinkle products.