This study focuses itself on designing a guide for workplace self-directed lifelong learning and assessment in distance learning. The areas the guide is designed on are: ①diagnosing learners’ needs, ②formulating self-learning goals, ③identifying human and material resources, ④selecting and implementing appropriate SDL strategies and ⑤evaluating own performance. The five instruments comprise a comprehensive qualification framework where each of the five is placed under the circular relationship nexus so that upward and downward interplay among each element works functionally. Task of designing a guide for workplace self-directed lifelong learning and assessment in distance learning is suggested to be a 21c challenge each nation faces in knowledge-based digital and globalization era.