Purpose - In 2022, the United States introduced Creative Helpful Incentives to Produce Semiconductors for America Act, which strengthened the export control on China’s chips, semiconductors, and other products. The scientific and technological relation between China and the United States is in a tense state, which has a negative impact on the complementary development of technology between China and the United States, as well as the development of China’s semiconductor industry. In the current situation of the scientific and technological relation between China and the United States, this paper hopes to play a certain reference role in the faster and better development of China’s semiconductor industry. Design/Methodology/Approach - This paper uses literature analysis, qualitative analysis and case analysis to elaborate on the general situation of the semiconductor industry and the development process of China’s semiconductor industry under the global semiconductor industry, and analyzes the development, present situation and future of Sino-us scientific and technological relations. Findings - This paper discusses the development problems and opportunities of China’s semiconductor industry under the Sino-US science and technology relations, and puts forward the development strategy of China’s semiconductor industry under the Sino-US science and technology relations. This paper can bring enlightenment to the development of China’s semiconductor industry under the Sino-US science and technology relations. Research Implications - Through the study of the development opportunities and strategies of China’s semiconductor industry under the Sino-US scientific and technological relation, Chinese semiconductor enterprises can better cope with the impact of the United States on the development of China’s semiconductor industry, grasp the development opportunities of the semiconductor industry, and achieve the development goals of the semiconductor industry in the difficult situation.