Spatial structures as like dome structure have the different dynamic characteristics from general rahmen structures. Therefore, it is necessary to accurately analyze dynamic characteristics and effectively control of seismic response of spatial structure subjected to multi-supported excitation. In this study, star dome structure that is subjected to multi-supported excitation was used as an example spatial structure. The response of the star dome structure under multiple support excitation are analyzed by means of the pseudo excitation method. Pseudo excitation method shows that the structural response is divided into two parts, ground displacement and structural dynamic response due to ground motion excitation. And the application of passive tuned mass damper(TMD) to seismic response control of star dome structures has been investigated. From this numerical analysis, it is shown that the seismic response of spatial structure under multiple support seismic excitation are different from those of spatial structure under unique excitation. And it is reasonable to install TMD to the dominant points of each mode. And it is found that the passive TMD could effectively reduce the seismic responses of dome structure subjected to multi-supported excitation.