The fracture of mechanical structure is caused by internal cracks in the material. Particularly, the fracture can also be seen to happen under the stress that is lower than yield strength in case of high strength steel because of the crack happening from the defect inside the material. In this study, high strength steel with four holes near the center crack were designed by angle and fatigue experiments, and the simulation analyses to verify the experimental results were carried out. As the results of this study, the crack growth rates are shown to be 0.000485, 0.000434 and 0.000422 respectively at the inclined angles of center crack as 22.5°, 45° and 67.5°. The maximum deformation energies become 0.0848mJ, 0.0603mJ and 0.0582mJ respectively at the inclined angles of center crack as 22.5°, 45° and 67.5°. It is thought that this study result can be utilized as the basic data at the study on the material existing with the defects of crack and hole.