Since Russia-Ukraine war, India and the United States has enhanced their cooperation as evidenced by the recent engagements. Multiple meetings by officials and leaders including two Quad and 2+2 dialogue summits, have provided a clear stance on each country’s perspective on the recent conflict. The US-India dispute regarding Russia-Ukraine war demonstrates that it is a stress test for the US-India ties, as well as a test of the US leadership in the global politics. The balancing act required to settle the differences between the two countries will have implications for the Indo-Pacific region as well as global security, even though the disagreements are not yet mutually incompatible. Strengthening ties with the US is now a tightrope walk for India. While there are differences between the two countries in Ukraine, the real challenge is turning these differences into opportunities. The paper deals with the different issues arising from the Russia and Ukraine conflict in the context of US-India interface.