The mosquito is a dangerous disease vector, which transfers various diseases like dengue virus, Zika virus and malaria.This study used an alternative way of mosquito repellent agents rather than chemical repellents such as DEET. We haveemployed a novel emitters of ultra-sonic sounds, which showed repellent effects to mosquito behaviors that avoid ultra-sonicsounds. Using NGS analysis after ultrasonic treatment, we found that some subsets of sensory and other related geneswere affected, indicating that ultrasonic sounds affects gene expression associated with host finding behaviors in Aedesaegypti. Additionally, we performed electrophysiological recording and behavior assay testing repellency in a chamberin Culex pipiens, which is the most common species in Korea.