The purpose of this study is to provide technical issues in upgrade and modification of fuel handling equipment at operating nuclear power plants. The improvement for safety function and performance enhancement of fuel handling equipment has been going on for 20 years since the early 2000’s. This improvement is recently focused on the replacement of components through the performance analysis and the operation and maintenance plan based on replacement cycle of its component. Additionally, it is required to secure spare parts so that it can be operated at all times with compatibility and standardization to other domestic nuclear power plants. The fuel handling equipment is consisted of refueling machine, upender and carriage of fuel transfer system, spent fuel handling machine, new fuel elevator and various tools, and the equipment are linked in systematic interlocks. Fuel handling is a critical task during a nuclear power plant refueling outage. Even minor component defects may stop operation of the whole system and have a significant impact on the overall system process. To achieve this goal, major components that are expected to be replaced for reliable operation are summarized as follows; 1) motor assembly with AC servomotors and driver for bridge, trolley and hoist of refueling machine and spent fuel handling machine, 2) winch motor and drive for upender and carriage of fuel transfer system, 3) operator control console with a HMI PC base PLC (Programmable Logic Controller) control system, 4) positioning and load weighing sensors such as an encoder and a load cell with its support for periodic calibration and maintenance, 5) main power drapped style festoon cable assembly for bridge of refueling machine, 6) pneumatic control assembly for gripper operation of refueling machine, 7) active components (e. g., air motor, hydraulic cylinder and limit switch) to be removable and reinstallable without requiring the water level to be lowered. It is advisable to utilize such various information as it can help to improve reliability of fuel handling as a critical path in upgrade and modification of fuel handling equipment at operating nuclear power plants.