Piloti-type structures with vertical irregularity are vulnerable to earthquakes due to the soft structure of the first story. Structural characteristics of buildings can significantly affect the seismic loss function, calculated based on seismic fragility, and therefore need to be considered. This study investigated the effects of the number of stories and core locations on the seismic loss function of piloti-type buildings in Korea. Twelve analytical models were developed considering two variations: three stories (4-story, 5-story, and 6-story) and four core locations (center core, x-eccentric core, y-eccentric core, and xy-eccentric core). The interstory drift ratio and peak floor acceleration were assessed through incremental dynamic analysis using 44 earthquake records, and seismic fragility was derived. Seismic loss functions were calculated and compared using the derived seismic fragility and repair cost ratio of each component. The results indicate that the seismic loss function increases with more stories and when the core is eccentrically located in the piloti-type structure model. Therefore, the uncertainty due to the number of stories and core location should be considered when deriving the seismic loss function of piloti-type structures.