Clusters of galaxies are believed to constitute a population of astrophysical objects potentially able to emit electromagnetic radiation up to gamma-ray energies. Evidence of the existence of non-thermal radiation processes in galaxy clusters is indicated from observations of diffuse radio halos, hard X-ray and EUV excess emission. The presence of cosmic ray acceleration processes and its confinement on cosmological timescales nearly inevitably yields in predicting energetic gamma-ray emission, either directly deduceably from a cluster's multifreqency emission characteristics or indirectly during large-scale cosmological structure formation processes. This theoretical reasoning suggests several scenarios to actually detect galaxy clusters at gamma-ray wavelengths: Either resolved as individual sources of point-like or extended gamma-ray emission, by investigating spatial-statistical correlations with unidentified gamma-ray sources or, if unresolved, through their contribution to the extragalactic diffuse gamma-ray background. In the following I review the situation concerning the proposed relation between galaxy clusters and high-energy gamma-ray observations from an observational point-of-view.