Maintaining adequate residual chlorine concentration is an important criteria to provide secure drinking water. The chlorine decay can be influenced by unstable flow due to the transient event caused by operation of hydraulic devices in the pipeline system. In order to understand the relationship between the transient event and the chlorine decay, the probability density function based on the water demand curve of a hypothetical water distribution system was used. The irregular transient events and the same number of events with regular interval were assumed and the fate of chlorine decay was compared. The chlorine decay was modeled using a generic chlorine decay model with optimized parameters to minimize the root mean square error between the experimental chlorine concentration and the simulated chlorine concentration using genetic algorithm. As a result, the chlorine decay can be determined through the number of transients regardless of the occurrence intervals.